Jeffrey Milbrandt, M.D., Ph.D.

jmilbrandt@wustl.edu
James S. McDonnell Professor and Head, Department of Genetics

Professor of Pathology & Immunology, Medicine and Neurology




 

Aldrin Kay Yuen Yim

yim@wustl.edu
Graduate Student

Aldrin has always maintained a dual-interest in both computer science and medical research. He is currently a Ph.D. candidate in the Computational and System Biology Program, Washington University School of Medicine. Aldrin received his B.Sc. and M.Phil. degree in Biochemistry from The Chinese University of Hong Kong. Before joining Dr. Milbrandt’s lab, his research primarily focused on Bioinformatics, which led to multiple discoveries including a novel major allergen class (designated as Group 24th Major allergen by WHO/IUIS Allergen Nomenclature subcommittee) through multi-omic approach analysis of dust mite (JACI, 2015). His current research aims to understand the heterogeneity of cell types within the peripheral nervous system, and their various roles in neurological disease formation. Apart from research work, Aldrin is also engrossed in biotech entrepreneurship.



Amber Hackett

a.hackett@wustl.edu
Postdoctoral Fellow

Amber Hackett received a Bachelor of Science in Biomedical Engineering at Virginia Commonwealth University in 2011. During this time, she worked in the lab of Dr. Jeffrey Dupree studying the role of sphingolipids in central nervous system myelin development and maintenance. Amber received a Ph.D. in Neuroscience at the University of Miami in 2016. For her thesis project, she studied glial scar formation and remyelination after spinal cord injury at the Miami Project to Cure Paralysis in the lab of Dr. Jae Lee. She is now a Postdoctoral fellow in the Milbrandt lab studying how Schwann cells support axons. To do this, she is perturbing several major metabolic pathways in Schwann cells in vitro and in vivo to determine the impact on axons.



Denis Avey

avey.denis@wustl.edu
Postdoctoral Research Scholar

Dennis Avey received a B.S. in Biology and Ph.D. in Cell and Molecular Biology from Florida State University. He joined the Milbrandt and Mitra labs as a postdoctoral researcher in the spring of 2016. His primary research goal is to characterize the heterogeneity of dopamine neurons, which serve a central role in diverse biological processes, including physical movement, reward and aversion, and mood/emotion. They are also dysregulated in a vast array of chronic/complex neurological disorders, such as Parkinson’s disease, depression and drug addiction. His project is at the intersection of neuroscience, genetics, molecular biology, pharmacology and psychiatry. When he’s not in the lab, Dennis enjoy drumming (with a local band, Hellen Back), rock climbing, soccer, and roller hockey.



John Bermingham

jbermingham@wustl.edu
Research Associate Professor

John Bermingham obtained a B.A. in Biology from Yale, and a Ph.D. from the University of Colorado, Boulder, where he studied the homeotic gene Antennapedia in Matthew Scott’s lab.  Following a year of postdoctoral work on the Factor VIII coagulation gene in Jane Gitschier’s lab at UCSF, John moved to Geof Rosenfeld’s lab at UCSD, where he studied SR splicing factors, and generated mice that lack the transcription factor Oct-6(Pou3f1; SCIP; Tst1).  He found that these mice display specific CNS defects and a delay in peripheral myelination. In his own laboratory at the McLaughlin Research Institute in Great Falls, MT, John obtained NIH funding to study Oct6 target genes in peripheral nerve.



Tasha Crawford

tcrawford@genetics.wustl.edu
Lab Assistant

Sandretta (Tasha) Crawford has worked in the Milbrandt Lab for 29 years. Tasha is a lab assistant to all. She takes care of stocking supplies, making standard lab reagents, and keeping the lab clean and straightened. Tasha is the mother of Nathan and she loves her coffee (and her coffee machine).



Kow Essuman

kowessuman@wustl.edu
MD/PhD Student

Kow Essuman is a graduate student in the M.D./Ph.D. program at Washington University School of Medicine. He received a Bachelor of Science (Summa Cum Laude) in Biochemistry from Temple University in 2010. From 2010-2012, Kow spent time in the lab studying the role of microRNAs and PGC-1alpha in liver regeneration. He began his studies in the MD program at Washington University in 2012, and he is currently defining molecular pathways that underlie the axon self-destruction program in neurons. He hopes his findings will identify novel therapeutic targets against diseases characterized by axonal degeneration. Kow is a Howard Hughes Medical Institute Medical Fellow, and a member of the Gold Humanism Honor Society. He enjoys listening to select straight-ahead live jazz music.



Tim Fahrner

tfahrner@genetics.wustl.edu
Research Lab Supervisor



Joe Ippolito

ippolitoj@mir.wustl.edu
Instructor, Radiology



Sungsu Kim

sungsukim@wustl.edu
Instructor

Sungsu Kim’s research goal is to understand the pathogenic mechanisms underlying metabolic complications of the nervous system. In particular, he is interested in neuropathies in human metabolic disorder such as diabetes and Alzheimer disease (AD). In addition, Sungsu’s background is in molecular and cell biology, biochemistry, and Drosophila melanogaster (fruit fly) and mouse genetics, with expertise in high-throughput image/data acquisition and computational analysis. As Ph.D. graduate student under the mentorship of Dr. Aaron DiAntonio, Sungsu developed image-based membrane trafficking assays, and applying Drosophila genetics tools, successfully characterized functions of the novel type 1 diabetes and autoimmune disease susceptibility gene ema/CLEC16A in the endosomal trafficking and autophagy. To study diabetic peripheral neuropathy, he has explored potential metabolic interaction between Schwann cells and neurons/axons during his postdoctoral training in Dr. Milbrandt’s lab.



Kimberly Kruse

kkruse@wustl.edu
Research Technician II

Kimberly Kruse got a B.S. in agriculture with specialization in animal science, minor in equine studies, from Truman State University in 2009. She received her M.S. in animal bioscience from the University of Edinburgh in 2012. Her thesis was on gut macrophage populations in cases of equine dysautonomia. Kimberly started at WashU as an animal care technician with DCM in early 2014 and was notified not long after of an opening in Dr. Milbrandt’s lab. She now works as a research technician caring for the extensive mouse colony. In addition, she assists with surgical procedures and behavioral studies, performs genotyping, and aids in other procedures–tissue fixation, slide preparation, histology, etc.–as needed. Previously, she had worked as an animal care tech at the Humane Society, as a groomer with Petco, and as a keeper/gift shop supervisor at the St. Louis Zoo. She has volunteered at the Endangered Wolf Center for three years and previously volunteered at Longmeadow Rescue Ranch for the Humane Society of Missouri for two years. Kimberly is an avid rock climber and also plays sand and indoor volleyball.



Matthew Lalli

mlalli@wustl.edu
Postdoctoral Research Scholar

Matthew Lalli is a post-doc in the Milbrandt and Mitra labs interested in understanding neurological diseases using patient derived stem cells. He is trying to apply new technologies to improve disease-in-a-dish modeling by expanding the number of relevant cell types we can generate. Through Cas9-based transcriptional modulation of disease-causing genes, he hopes to discover molecular underpinnings of disease phenotypes. Altogether, these projects have the potential to identify novel targets for treating neurological diseases such as Alzheimer’s and autism.



Xianrong Mao

maox@wustl.edu
Staff Scientist

Xianrong Mao received a B.S. from Lanzhou University in China, and a Ph.D. from the University of Arkansas for Med Science. His research background is neuroscience, in particular with genetic and metabolic approaches. Currently his focus is identifying the signaling pathways activating SARM1, the central molecule controlling axon degeneration. Mao is investigating how activity SARM1 is activated in response to axon damage.  This will also allow scientists to find tools to suppress SARM1 activity and further down the road will give them therapeutic intervention to block axon degeneration.



Bryan McGill

bemcgill@wustl.edu
Instructor of Neurology

Bryan McGill completed his undergraduate studies at Denison University and his medical and graduate school studies at Baylor College of Medicine. He is an Instructor in the Division of Pediatric and Developmental Neurology in the Department of Neurology. He sees patients at St. Louis Children’s Hospital. Bryan’s areas of clinical interest include autism, intellectual disability, and neurogenetic disorders including Fragile X syndrome and Cornelia de Lange syndrome. His research interest is in understanding the neurobiologic basis of autistic spectrum disorders. Bryan is currently conducting research in the Milbrandt lab, where he is studying mouse models of these disorders and obtaining advanced training in neurogenetic techniques. As a parent of 2 young children, Bryan’s hobbies involve trips to the park, changing diapers, and reading bedtime stories.



Peter Wang

peterwang@wustl.edu
Predoctoral Trainee



Rachel McClarney

rmcclarney@wustl.edu
Research Technician

Rachel McClarney got a B.S. in Animal Science from the University of Missouri – Columbia. Prior to her employment at Washington University, she was an assistant at House Springs Animal Clinic, where she still works on Saturdays. In September Rachel will have worked at House Springs for 12 years.



Yo Sasaki

sasaki@wustl.edu
Ph.D., Research Assistant Professor

Yo Sasaki was born and raised in Japan. He attended Tokyo University of Agriculture and Technology (B.S.) and Gunma University School of Medicine (Ph.D.) and decided to come to U.S. Yo is interested in the mechanism of axon degeneration. Axon degeneration is a common and early step of many neurological disorders and could be a useful therapeutic target for neurodegenerative diseases. Using injury-induced axon degeneration as a model, Yo and his colleagues discovered that overexpression of the NAD+ biosynthetic enzyme NMNAT1 can block axon degeneration. They identified other enzymes and substrates in NAD+ biosynthetic pathways that significantly delay axon degeneration. Based on these findings, Yo’s research is focused on the identification of axon survival signaling pathways that are linked to NAD+ metabolism.



Kelli Simburger

ksimburger@genetics.wustl.edu
Research Technician

Kelli has worked in the Milbrandt lab for 28 years. She does much of the cloning for the lab along with a lot of general lab support. Kelli enjoys hiking, biking, travel and spending time with her family.



Amy Strickland

amy.strickland@wustl.edu
Research Lab Manager

Amy Strickland got a B.S. in psychobiology from University of Evansville in 1997. She received an M.S. in Criminlogy & Criminal Justice from UMSL in 1999. She is the Milbrandt lab manager. She’s been employed by Washington University Medical School since 1998 and been in the Milbrandt lab since 2002. Amy received the Dean’s Research Support Award 2016. She is the mother of three very active children and enjoys watching and coaching all kinds of sports in her “free” time, as well as working out.



Daniel Summers

dsummers@wustl.edu
Post Doctoral Research Associate

Daniel Summers’ work revolves around how protein homeostasis pathways influence axon health and susceptibility to disease.  His interest in this topic began as a graduate student in the lab of Doug Cyr at UNC-Chapel Hill, where he investigated how chaperone networks recognize unfolded proteins and regulate their disposal. As a joint postdoctoral fellow in the Milbrandt and DiAntonio labs, Daniel identified fundamental properties in the pro-degenerative factor SARM1 that promote the destruction of injured axons.  He is merging his interests in protein homeostasis and axon health to characterize novel pathways that regulate the degradation of neuron survival factors in the axon.  Daniel is currently supported by a grant from the Muscular Dystrophy Association with the hope of identifying new and potent avenues for therapeutic intervention in neurological disorders.




 

Debbie Peterson

debbie@genetics.wustl.edu
Assistant to the Chair