Postdoctoral positions to develop methods to drive differentiation of fibroblasts and iPSCs into glial and neuronal subtypes using Cas9/CRISPR technology.

 

The laboratories of Jeff Milbrandt and Rob Mitra invite mature, highly motivated candidates to apply for positions as joint postdoctoral fellows in the Department of Genetics at Washington University in St. Louis. These fellows will explore the use and optimization of Cas9 proteins as RNA-guided, artificial transcription factors (ATFs). Cas9-based ATFs will then be used to drive differentiation of fibroblasts and/or modified iPSCs into glial and neuronal subtypes. These cells, either harboring disease-associated variants or wildtype, will be used in targeted drug and genetic screens to identify and modulate pathways that are central to pathophysiology of neurodegenerative disease phenotypes. This project is funded by a grant from the NIH.

Multiple full-time positions are available immediately and are funded for three years, with the possibility of extension.

The ideal applicants will have:
1. PhD or MD/PhD in biological sciences or related fields
2. Experience in molecular biology or genomics.
3. Candidates with programming skills will be given priority (Python and R are preferred)
4. Good spoken and written communication skills
5. In addition, applicant must be able to visit St Louis for potential interviews without visa application.

About Washington University: Washington University School of Medicine (WUSM) has a rich history of success in research, education and patient care, earning it a reputation as one of the premier medical schools in the world. The University is internationally known for studies in genetics, neuroscience, and addiction.

How to Apply:
Applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Drs. Jeff Milbrandt and Rob Mitra at cas9project@genetics.wustl.edu.

 

Postdoctoral positions to study the role of glial/axonal metabolic interactions in neurodegenerative disorders.

We invite mature, highly motivated candidates to apply for positions as postdoctoral fellows in our laboratory in the Department of Genetics at Washington University in St. Louis. These fellows will explore the role of axonal/glial interactions, particularly metabolic support, in neurodegenerative disorders. This work seeks to understand the role of NAD-regulated processes as well as other metabolic pathways in axon stability. Much of our focus is aimed at understanding the regulation of Sarm1 and its downstream signaling pathways that control axon maintenance. The role of glia in supporting axon health will also be explored; in particular, we are interested in the effects of abnormal glial metabolism on the loss of axon stability and function that are associated with peripheral neuropathy. These projects are funded by grants from the NIH.

Full-time positions are available immediately and are funded for three years, with the possibility of extension.

The ideal applicants will have:
1. PhD or MD/PhD in biological sciences or related fields
2. Experience in molecular biology, neuroscience or genomics.
3. Good spoken and written communication skills
4. In addition, applicant must be able to visit St Louis for potential interviews without visa application.

About Washington University: Washington University School of Medicine (WUSM) has a rich history of success in research, education and patient care, earning it a reputation as one of the premier medical schools in the world. The University is internationally known for studies in genetics and neuroscience.

How to Apply:
Applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Dr. Jeff Milbrandt at axonal@genetics.wustl.edu.