660 S. Euclid Ave.
Campus Box 8232
St. Louis, MO 63110
“Many of Jeff’s discoveries have the potential to be important for understanding and treating ALS, and they may also be helpful for other neurodegenerative disorders like Parkinson’s disease, Alzheimer’s disease and multiple sclerosis,” says David Holtzman, MD, the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology.
James S. McDonnell Professor and Chair, Department of Genetics, Washington University School of Medicine
Our laboratory studies the biological function of the GFL family of neurotrophic factors (GDNF, neurturin, persephin and artemin) that constitute the ligands for the Ret tyrosine kinase receptor, which is mutated in multiple endocrine neoplasia syndromes as well as thyroid cancers. We are characterizing mouse models lacking components of this ligand-receptor family, and we are investigating the downstream signaling events mediated by Ret activation. We are also studying the role of several genes, including Egr1, Nab2, a homeodomain protein Nkx3.1 and the tumor suppressor PTEN, in the development and progression of prostate cancer. We are characterizing mouse models of prostate cancer that we have developed and are using microarray screens and other functional genomics techniques to identify additional gene products that play a role in this disease.
•1978: MD, Washington University, St. Louis
•1983: PhD, biochemistry, University of Virginia, Charlottesville
•1978-1980: Resident, pathology, University of Virginia, Charlottsville – See more at: http://www.siteman.wustl.edu/ResearcherProfile.aspx?id=&memid=90#sthash.2XweDC2J.dp