Milbrandt lab publishes paper on Schwann cell O-GlcNAcylation

Posted by on Jul 16, 2018 in Blog |

The Milbrandt lab published a paper recently on Schwann cell O-GlcNAcylation. The paper, “Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN,” appears in PNAS. Sungsu Kim, an instructor in the Department of Genetics and a member of the Milbrandt lab, is first author on the paper. Read the abstract...

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Milbrandt lab welcomes rotation student researching SARM1 activation

Posted by on Jul 5, 2018 in Blog |

The Milbrandt lab recently welcomed Caitlin Dingwall for a rotation project.  Caitlin received a B.S. in Molecular and Cellular Biology with Honors from the University of Illinois at Urbana-Champaign in 2015. For her Honors thesis, she worked in the lab of Dr. Phillip Newmark where she pursued dual projects investigating the role of matrix metalloproteinases in stem cell homeostasis in the freshwater planarian Schmidtea mediterranea and...

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Milbrandt lab publishes paper on NAD+ metabolism and Schwann cell dedifferentiation

Posted by on Jun 28, 2018 in Blog |

Yo Sasaki, Ph.D., Research Associate Professor in the Department of Genetics and a member of Dr. Jeff Milbrandt’s lab, and Amber Hackett, Ph.D., a postdoctoral fellow in the Milbrandt lab, recently published a paper. The paper, “Dysregulation of NAD+ metabolism induces a Schwann cell dedifferentiation program,” appears in the Journal of Neuroscience. Read more about the paper...

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Milbrandt lab postdoc publishes paper on single cell RNAseq and morphine treatment

Posted by on Apr 24, 2018 in Blog |

Denis Avey, PhD, a postdoctoral researcher in the Milbrandt and Mitra labs, is first author on a newly-uploaded preprint article. The paper, “Single cell RNAseq uncovers a robust transcriptional response to morphine by oligodendrocytes” can be accessed via bioRxiv. Sumithra Sankararaman, a research scientist in the Mitra lab, Aldrin K. Y. Yim, a graduate student in the Milbrandt lab, Ruteja Barve, PhD, Instructor of Genetics, Robi D. Mitra,...

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Kow Essuman and colleagues publish paper in Current Biology

Posted by on Jan 25, 2018 in Blog |

The Milbrandt lab had a paper published recently in Current Biology. The paper, “TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes,” shows that TIR domain proteins from both bacteria and archaea cleave NAD+ into nicotinamide and ADP-ribose (ADPR), with catalytic cleavage executed by a conserved glutamic acid. Kow Essuman, an M.D./Ph.D. student in the Milbrandt lab, is first author on the paper, with co-authors Dr....

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