Dan Summers publishes his paper on Sarm1-dependent neuronal death and mitochondrial dysfunction in J Neuroscience

Posted by on Sep 21, 2014 in Blog |

Congratulations Dan! This work demonstrates that neuronal death by mitochondrial inhibition is dependent on the TLR adaptor protein Sarm1. Inhibitors of canonical programmed cell death pathways such as apoptosis, necroptosis, and parthanatos do not block neuronal death and axonal degeneration triggered by mitochondrial depolarization. These studies highlight the central role for Sarm1 in a novel form of programmed cell destruction we term...

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Axonal degeneration

Posted by on Sep 4, 2014 in Blog | 0 comments

Axonal degeneration and glial/axonal interactions in disease Our lab studies the interactions between glia and axons that are required for proper nerve function. Axonal dysfunction and degeneration are early and causative events in nervous system disorders ranging from traumatic injury to inherited and acquired peripheral neuropathies to neurodegenerative diseases like Alzheimer’s disease and Multiple Sclerosis. Axonal degeneration is an...

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