Jeffrey Milbrandt

Email: jmilbrandt@wustl.edu

Our laboratory seeks to understand the molecular mechanisms that lead to axon degeneration and the diseases that stem from this degenerative process. We focus our studies on axon/glial interactions and the responses of neurons and glia to axon injury and disease. In particular, we aim to define, in studies performed collaboratively with Aaron DiAntonio’s lab, the molecular program responsible for dismantling injured and/or unhealthy axons. We also study the mechanisms by which disruption of glial cell metabolism leads to axon dysfunction and degeneration. Our laboratory utilizes cutting-edge technologies including Cas9-mediated genome engineering, metabolomics, and high-content screening to manipulate and analyze axon/glial interactions in health and disease. In our research, we utilize mutant mice, primary neuronal and Schwann cell cultures, and iPSC-derived neurons. Our overriding goal is to help develop new treatments for patients with neurodegenerative conditions through fundamental mechanistic research.

Lab News

Kow Essuman has paper published in Neuron

Kow Essuman is the lead author of a paper recently published in Neuron, titled: “The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration.” Daniel Summers, Yo Sasaki, Xianrong Mao, Dr. Jeff Milbrandt and Dr. Aaron DiAntonio are also authors of the paper. Read the study abstract...

Kow Essuman admitted to MD/PhD program at Washington University

Kow Essuman was admitted to the Medical Science Training Program (MSTP), a combined MD/PhD program at Washington University in St. Louis. Kow began his studies in the MD program at Washington University in 2012, and gained admission to the MSTP program in February 2017. He is currently defining molecular pathways that underlie the axon self-destruction program in neurons. He hopes his findings...

Peter Wang has joined the lab as a predoctoral trainee

Welcome Peter!

Aldrin Yim has joined the lab as a graduate student. Welcome Aldrin!

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4515 McKinley Ave.
Campus Box 8232 St. Louis, MO 63110
Phone: (314) 362-4652 | Fax: (314) 362-2157
Email: jmilbrandt@wustl.edu