Jeffrey Milbrandt


Our laboratory seeks to understand the molecular mechanisms that lead to axon degeneration and the diseases that stem from this degenerative process. We focus our studies on axon/glial interactions and the responses of neurons and glia to axon injury and disease. In particular, we aim to define, in studies performed collaboratively with Aaron DiAntonio’s lab, the molecular program responsible for dismantling injured and/or unhealthy axons. We also study the mechanisms by which disruption of glial cell metabolism leads to axon dysfunction and degeneration. Our laboratory utilizes cutting-edge technologies including Cas9-mediated genome engineering, metabolomics, and high-content screening to manipulate and analyze axon/glial interactions in health and disease. In our research, we utilize mutant mice, primary neuronal and Schwann cell cultures, and iPSC-derived neurons. Our overriding goal is to help develop new treatments for patients with neurodegenerative conditions through fundamental mechanistic research.

Lab News

Milbrandt lab postdoc publishes paper on single cell RNAseq and morphine treatment

Denis Avey, PhD, a postdoctoral researcher in the Milbrandt and Mitra labs, is first author on a newly-uploaded preprint article. The paper, “Single cell RNAseq uncovers a robust transcriptional response to morphine by oligodendrocytes” can be accessed via bioRxiv. Sumithra Sankararaman, a research scientist in the Mitra lab, Aldrin K. Y. Yim, a graduate student in the Milbrandt lab,...

Kow Essuman and colleagues publish paper in Current Biology

The Milbrandt lab had a paper published recently in Current Biology. The paper, “TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes,” shows that TIR domain proteins from both bacteria and archaea cleave NAD+ into nicotinamide and ADP-ribose (ADPR), with catalytic cleavage executed by a conserved glutamic acid. Kow Essuman, an M.D./Ph.D. student in the Milbrandt lab, is first author...

Mihir Vohra joins Milbrandt lab

Mihir Vohra has joined the Milbrandt lab as a postdoctoral researcher. Welcome,...

Rachel McClarney joins Milbrandt lab

Rachel McClarney has joined the Milbrandt lab as a research technician. Welcome,...

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4515 McKinley Ave.
Campus Box 8232 St. Louis, MO 63110
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