Jeffrey Milbrandt

Email: jmilbrandt@wustl.edu

Our laboratory seeks to understand the molecular mechanisms that lead to axon degeneration and the diseases that stem from this degenerative process. We focus our studies on axon/glial interactions and the responses of neurons and glia to axon injury and disease. In particular, we aim to define, in studies performed collaboratively with Aaron DiAntonio’s lab, the molecular program responsible for dismantling injured and/or unhealthy axons. We also study the mechanisms by which disruption of glial cell metabolism leads to axon dysfunction and degeneration. Our laboratory utilizes cutting-edge technologies including Cas9-mediated genome engineering, metabolomics, and high-content screening to manipulate and analyze axon/glial interactions in health and disease. In our research, we utilize mutant mice, primary neuronal and Schwann cell cultures, and iPSC-derived neurons. Our overriding goal is to help develop new treatments for patients with neurodegenerative conditions through fundamental mechanistic research.

Lab News

Peter Wang passes qualifying exam

Peter Wang passed his qualifying exam on June 13, marking a major checkpoint in his graduate studies. Congratulations,...

Jeff Milbrandt has paper published in PNAS

Jeff Milbrandt recently had a paper published in PNAS, titled: “mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells.” Dr. Bogdan Beirowski, principal investigator at the Hunter James Kelly Research Institute at the State University of New York, is lead author on the paper. Keit Men Wong, a Ph.D. student at the State University of New...

Amber Hackett joins Milbrandt Lab

Amber Hackett recently joined the lab as a postdoctoral fellow. Previously, Amber received her PhD in Neuroscience at the University of Miami. Her thesis project focused on glial scar formation and remyelination after spinal cord injury. Amber joined the Milbrandt lab in...

Kow Essuman has paper published in Neuron

Kow Essuman is the lead author of a paper recently published in Neuron, titled: “The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration.” Daniel Summers, Yo Sasaki, Xianrong Mao, Dr. Jeff Milbrandt and Dr. Aaron DiAntonio are also authors of the paper. Read the study abstract...

Read More

4515 McKinley Ave.
Campus Box 8232 St. Louis, MO 63110
Phone: (314) 362-4652 | Fax: (314) 362-2157
Email: jmilbrandt@wustl.edu